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Despite the fact that tobacco carcinogens mediate inactivation of numerous tumour suppressor genes via epigenetic mechanisms, and the fact that tobacco smoke initiates and maintains the malignant phenotype of lung cancer cells, its contribution to the prognosis of lung cancer patients remain poorly understood 8

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The seminal plasma supports and protects spermatozoa from pathological levels of ROS through free radical scavengers such as ascorbate, alpha-tocopherol, uric acid, and ROS-metabolizing enzymes such as superoxide dismutase (against superoxide), catalase (against hydrogen peroxide), and glutathione peroxidase (against glutathione peroxide) [110]

Therefore, SII in this context may partly function as a marker of the overall inflammatory burden, which is heightened by smoking but also influenced by other factors

After smoking a cigarette on those stairs in-between, new neighbor guy comes to me and says, Hey, sorry to bother you