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We hypothesized that providing nicotine from ENDS in addition to nicotine skin patches would promote smoking reduction relative to non-nicotine control ENDS

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21 Furthermore, in individuals with multiple sclerosis who smoke, there is an increased frequency of GPR15 + CD4 + T cells exhibiting Th17-like characteristics, implicating GPR15 as a potential link between environmental exposure and autoimmune pathogenesis

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Uneven packing or a loose roll is a common cause of uneven burning