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Upon direct comparison between GHNC and surgical biopsy findings in a previous study, H-pattern volume ratios at biopsy sites were found to be significantly correlated with histologically identified honeycombing ( r = 0.355

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The aforesaid results would indicate that p-BSQ is a major highly reactive harmful oxidant occurring in high concentrations in cigarette smoke, and it is possibly responsible for the oxidative damage of proteins and DNA leading to degenerative diseases and cancer

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