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Open systems refer to the Direct To Lung devices or vape mod box which have a larege battery capacity, tank, coil, a mouthpiece and the e-liquid as interchangeable elements

Interestingly, long-term nose-only exposure for 1 month caused a significant increase of ROS in the heart accompanied with decreased heart GSH concentrations in exposed mice, indicating depletion of the antioxidant, which increases heart tissue's vulnerability to oxygen free radical damage [199]

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[36] Separately, local policies have continued to expand tobacco-free rules at professional sports venues: in October 2025, the Detroit City Council approved an ordinance prohibiting smokeless tobacco (including nicotine pouches) in Detroit professional sports stadiums (including Comerica Park), with refusal to comply subject to a misdemeanor and a $100 fine