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Tobacco use causes many types of cancer CDC Online Newsroom CDC Tobacco use and Health. Part 2: What you need to know about smoking communitymedicine4all Smoking is a major cause of cardiovascular disease, which is the single leading cause of death in the U.S. Smoking causes one of every five deaths from cardiovascular disease. Learn more about number of deaths due to cigarette smoking Projected numbers of deaths from tobacco during the 21st Tobacco and nicotine
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