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Most trials are in Phases II and III , aiming to validate new immunotherapies, molecular-targeted agents, or combinations with chemotherapy and radiation

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[92] identified the differentially expressed lncRNA in smoking and non-smoking patients with COPD through RNA sequencing and bioinformatics analysis and found that ninety-six lncRNA were identified in non-smoking patients, while forty-four lncRNA were identified in smoking patients with COPD

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