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Nicotine is a marker for other toxic components of thirdhand smoke, but is also a concern in itself as nicotine can be changed into the highly toxic and carcinogenic tobacco-specific nitrosamine NNK, as shown by researchers at Lawrence Berkeley National Laboratory

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The essence of these enforcements is to significantly reduce the morbidity and mortality as a consequence of the widespread use of combusted tobacco products, which is the leading cause of preventable death in the United States