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3.3 Classical monocytes replenish the AM pool in smoke-induced lung inflammation Dimensionality reduction analysis on the pulmonary immune cell population suggested a potential link between the CMo and IM clusters, which is supported by previous studies demonstrating CMo differentiation into IM as well as MoAM ( Figure 2B )

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Notably, these findings suggested that the differentially expressed protein Crip2 may contribute to the effects of smoking on the heart and cardiovascular systems