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[92] The Royal College of General Practitioners stated in 2016 that "To date 42 chemicals have been detected in ENDS aerosol though with the ENDS market being unregulated there is significant variation between devices and brands." [93] E-liquid nicotine concentrations vary

Public Health England, Cancer Research UK, ASH and the Royal College of Physicians all say that vaping is safer than smoking traditional cigarettes

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When nicotine reaches the brain, it Nicotine also affects areas in the brain that play a part in: breathing memory appetite heart rate Using nicotine for an extended period leads to changes in the balance of chemical messengers in the brain

Legal actions are ongoing in several states, with the situation being slightly different in each