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Instead, there is a clear need to aggressively optimize medical therapy which represents one potentially modifiable variable to offset the multiplicity of negative cofactors associated with active smoking status that likely have a detrimental role in the course and severity of IBD, yet are not so easily modifiable, including socioeconomic and educational status, dietary behaviors and medication (non)adherence

So, finding the right dose is an ongoing situation

and "(B) includes tobacco, in any form, that is functional in the product, which, because of its appearance, the type of tobacco used in the filler, or its packaging and labeling, is likely to be offered to, or purchased by, consumers as a cigarette or as roll-your-own tobacco

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Monitor all patients for active TB during treatment, even if initial latent TB test is negative