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Smoking is the major risk factor for COPD, and cigarette smoke (CS)-induced oxidative stress can lead to the damage of airway epithelium and compromise the barrier function, which is the initial step and pathological basis of COPD progression [3,4,5,6]

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Supplemental table 1 presents the strategy used to search PubMed, Embase, and Web of Science up to 6 August 2019

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