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Neuromodulation by the immune system: a focus on cytokines

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45 Interestingly, while UBE1 expression remains unchanged in human heart failure, experimental studies have shown that overexpression of UBE1 or UBE6 in neonatal rat ventricular cardiomyocytes (NRVCMs) increases the ubiquitination of Nav1.5, a major transmembrane protein essential for cardiomyocyte depolarization

Ranjan A, Ramachandran S, Gupta N, Kaushik I, Wright S, Srivastava S, et al

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