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The knockdown of FOXC1 could decrease the subpopulation of CD133 + cells, and the associated genes, such as NANOG, ABCG2, SOX2 , and Oct4 , are also downregulated, and the chemo-sensitivity for cisplatin, docetaxel, and gefitinib is also increased (76)

The illegal cigarette trade grows in both rural and urban areas

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Because of this dependence, smokers feel a constant need to smoke to avoid withdrawal symptoms such as irritability and anxiety

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