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Users may find themselves transitioning to lower-risk products for recreational use, or even switching entirely, even if they initially had no intention of quitting smoking

Despite recognizing that tobacco is unhealthy and harmful, to quit smoking is not an easy task

As Ribisl points out, however, making cigarettes illegal would criminalize the behavior of more than 40 million tobacco users in the U.S

While it can aid in reducing or replacing cigarette consumption, it is not officially recognized as a smoking cessation tool

Indeed, study design factors such as species, tissue, sex and experimental platforms all showed strong influence on the DEGs detected