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Amongst humans, split-tipping led to significant reductions in MLE for smokers of 1-mg tar products but not for smokers of higher tar cigarettes

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[38] Standards [edit] E-liquid manufacturing requirements under the US Food and Drug Administration (FDA) rules include report user fee information, pay user fees, register their establishment and submit list of products, including labeling and advertisements, submit health documents, submit ingredient listing, include required warning statements on packages and advertisements, submit quantities of harmful and potentially harmful constituents, and submit a modified risk tobacco product application