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Ulcerative colitis is a chronic inflammatory bowel disease in which the large intestine (colon) becomes inflamed and ulcerated (pitted or eroded), leading to flare-ups (bouts or attacks) of bloody diarrhea, abdominal cramps, and fever

[11] Half of these were exported to more than 20 countries worldwide including Armenia, Czech Republic, Egypt, Georgia, Israel, Japan, Lithuania, Moldova, Montenegro, South Korea and others

So, the answer is a strong yesquitting makes a big difference

The plateau between 2014 and 2017 was largely driven by the increasing availability and popularity of small very cheap supervalue packs