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The second reason is the cigarette accord because its way too subdued

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The airway epithelium provides the first line of defense against inhaled substances and the ability of the airway to clear mucus is critical to prevent obstruction and stave off infection 15

Polycyclic aromatic hydrocarbons contained in Cigarette smoke increase the activity of CYP 1A2 enzymes, and thus affects the metabolism of its substrates, several antipsychotics, e.g., olanzapine, haloperidol, clozapine, as well as some antidepressants (amitriptyline, clomipramine, doxepin, duloxetine, fluvoxamine, imipramine, mianserin, mirtazapine) and benzodiazepines (65)