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Among the ROS, aldehyds are the main compounds that are implicated in the process of tobacco-induced diseases (3)

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5 Although this did not occur systematically across jurisdictions, the warnings also appeared on print advertisements and billboards, by virtue of a mixture of voluntary agreements and legislation

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This effect is best understood in the context of gene promoters where DNA methylation can impair physical binding of transcription enhancers and promote the recruitment of methyl-CpG-binding domain proteins that increase chromatin condensation and thus decrease the DNA accessibility for the transcriptional machinery (Portela and Esteller, 2010)