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147 Ageing is characterized by quantitative and qualitative changes in the immune system (i.e., increased levels of pro-inflammatory cytokines and decreased levels of anti-inflammatory cytokines)

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This increased to 85% when the 4MP was combined with the PLCO m2012 risk prediction model and tested on samples collected in the year preceding diagnosis from individuals with at least 10 packyears of smoking (98% of the cohort)