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While M1 and other metabolites do not retain significant antimycobacterial activity, they can still impact cardiac safety

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[DOI] [PMC free article] [PubMed] [Google Scholar] 121.Zavala VA, Bracci PM, Carethers JM, Carvajal-Carmona L, Coggins NB, Cruz-Correa MR, et al

[Shurunbulali, Nur al-Idah] (2) The Legal Ruling on Smoking Cigarettes and Chewing Tobacco Tobacco is not considered an intoxicant, as it does not cause inebriation and is not mind-altering, so its legal ruling differs from that of alcohol and substance abuse drugs

[27] Sub-Saharan Africa [edit] Around 1600, French merchants introduced tobacco in what is now Gambia and Senegal