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In addition, for each biological replicate, 3 technical replicates were performed

Metabolites 12, 1145

However, with VIM DBS, effective tremor suppression can sometimes come with the price of worsening gait ataxia, a clinical observation that suggests that different neuronal coding mechanisms for tremor and ataxia lie within the same cerebello-thalamo-cortical loop [189]

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Low-Dose Naltrexone (LDN) provides a temporary blockade of opioid receptors resulting in a rebound effect, yielding an increase in endorphin production