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This code reflects harmful or hazardous use patterns (e.g., legal consequences, impaired functioning, risky behavior) without the hallmark features of dependence, such as loss of control, compulsive use, or prioritization of cannabis over other activities

This distinction is particularly relevant in adolescents, whose developing cardiovascular and nervous systems may be more susceptible to nicotines hemodynamic and neurochemical effects (7)

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If indeed a good response is achieved, the patient continues the treatment with 5 tablets per day (1 tablet every 2.5 h) on day 412, suspending smoking on day 5

[3] The tier poles were often supported by posts and cross beams, the space in between known as the "bents." The bents ranged in vertical spacing from 20 inches to five feet wide