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Even trace amounts of THC can lead to the production of detectable metabolites, so there is some risk of a positive drug test result

Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function [see Dosage and Administration (2.2)]

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Possible mechanisms include vaping-induced lung function limitations reducing oxygen supply during exertion, as well as systemic effects of vaping (such as carbon monoxide exposure, blood vessel dysfunction, or chronic inflammation) hampering exercise capacity (83)

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