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Key safety risks include: Increased sedation Both substances can cause drowsiness, and combining them may impair your ability to drive or operate machinery safely Heightened anxiety THC can paradoxically increase anxiety in some people, counteracting Lexapros benefits Cognitive impairment Memory, concentration, and decision-making abilities may be more severely affected when using both substances Unpredictable mood changes The interaction can create emotional instability, particularly during the first few weeks of treatment Serotonin syndrome risk Though rare, the combination may contribute to dangerous serotonin elevation What Healthcare Providers Say About Lexapro and Cannabis Most physicians advise caution when patients ask about combining cannabis with antidepressant medication like Lexapro

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