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Furthermore, a study design that includes both a cMRTP switching and a cessation arm (exposure to cigarette smoke for a few months followed by exposure to either cMRTP aerosol or fresh air for several months) is essential to assess (i) the effects of a change in exposure that mimics the intended use of cMRTPs (i.e., switching current smokers) and (ii) how this compares with the effects of smoking cessation

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