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The initial notes are a very bitter, acrid, and peculiar scent [6] [7] [8] followed by a complex green, spicy, woody, balsamlike fragrance

Nicotine has known pathological effects, mainly related to the excessive release of catecholamines, endothelial dysregulation and increased insulin resistance.90 Nicotine in electronic cigarettes has been shown to increase heart rate after overnight abstinence.91 Regarding lipid metabolism, nicotine in electronic cigarettes has been shown to increase the amount of circulating saturated fatty acids, decreasing the content of unsaturated fatty acids and inducing insulin resistance

PMID: 15790389

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There is potential there for managing down your nicotine intake, but the strongest cartridges aren't likely to be enough for heavier smokers