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Stub1, an E3 ubiquitin ligase, is acetylated at K287 by CBP/p300 under hypoxia, translocates to the nucleus, and regulates HIF-1/HIF-2 switch to attenuate pulmonary vascular remodeling in PH via non-E3 activity, with reduced K287 acetylation exacerbating disease (Czerwinski et al

The GEG bill was first mooted and tabled by former health minister Khairy Jamaluddin last year which,if it had been passed, would have made Malaysia the first country in the world to ban the sale of tobacco and vaping products to the next generation

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Civil war broke out among several factions and in 1976 the government responded with a wide-spread repression campaign known as the Red Terror, escalating the violence in 1977