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They also pulled it off without any of the historical baggage, giving the deceptive illusion that it was safe. Anne Schuchat, the principal deputy director of the federal Centers for Disease Control and Prevention, told Congress during a hearing in September that doctors believe nicotine salts allow the addictive chemical to cross the blood-brain barrier and lead to potentially more effect on the developing brain in adolescents. In a statement to The Times, Schuchat echoed her concern and said the salts allow particularly high levels of nicotine to be inhaled more easily and with less irritation than ingredients in previous e-cigarettes, and could enable nicotine dependence among youth

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Corey CG, Holder-Hayes E, Nguyen AB, Delnevo CD, Rostron BL, Bansal-Travers M, Kimmel HL, Koblitz A, Lambert E, Pearson JL, et al