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During Phase I, it undergoes microsomal oxidation [] and produces various metabolites such as cotinine, nornicotine, demethyl cotinine, trans-3-hydroxy-cotinine, and d-(3-pyridyl)--methylaminobutyric acid. [,] In Phase II, the metabolites undergo N- and O-glucuronidation and then get excreted through urine, faces, bile, saliva, sweat, and other routes

The carcinogenic chemicals in tobacco damage the DNA in cells in your mouth, which can lead to the growth of cancerous tumors

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One report suggests that teenagers as young as 16 are hooked on them, while they are becoming increasingly ubiquitous on university campuses and in school classrooms probably down to the fact that once in the mouth, they are easily concealed

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