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Nicotine constricts blood vessels, raises heart rate and blood pressure, and puts extra strain on the cardiovascular system, says Tory Spindle, PhD, an associate professor at Johns Hopkins who studies the behavioral pharmacology of nicotine and tobacco

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Now, the industry has grown from thousands in 2006 to several million worldwide, with an estimated 20,000 to 30,000 new e-smokers every week, according to Healy, whose company is expected to have $30 million in sales this year