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The Centers for Disease Control and Prevention (CDC) estimates that somewhere between 2.4 and 3.1 million people in the U.S

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Nevertheless, these data together paint a smoker epithelium that has been rendered more functionally monochromatic, collapsing on the secretory and proteosomal basal cell phenotypes at the expense of its normal defensive, interactive, and reparative roles essential to lung health and homeostasis