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Other studies in humans have shown a relationship among the count of circulating leukocytes, decline in lung function, and risk for early death from COPD (Chan-Yeung et al

Furthermore, increased [Ca 2+ ] m enhances mitochondrial fission and is associated with changes in homeostasis of fusion versus fission proteins (50, 65), and thus it may be that the altered fission with nicotine is downstream of nicotine effects on [Ca 2+ ] i and [Ca 2+ ] m : aspects that remain to be explored

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Zhang H, Sulzer D (2004)