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For the Velo Pouches in Study 1, nicotine uptake parameters (AUC 0-15 , AUC 0-240 , and C max ) increased with increasing product nicotine content, were significantly lower than those of UB cigarette, and were each significantly higher than those of NRT gum (Table 3)

[26] [27] In addition to high use by African Americans, menthol cigarettes are used disproportionately by adolescents, women, and lesbian, gay, bisexual, and transgender (LGBT) Americans

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The UK Committee on Toxicity (COT) highlighted significant reductions in levels of harmful and potentially harmful constituents (HPHCs) in the aerosol of HTP compared to cigarette smoke and stated that [t]here would likely be a reduction in risk for conventional smokers deciding to use heat-not-burn tobacco products instead of smoking cigarettes. COT added that [a] reduction in risk would also be experienced by bystanders where smokers switch to heat-not-burn tobacco products

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