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In particular, cigarette smoke acts as a double-edged sword that either exacerbates pathological immune responses or attenuates the normal defensive function of the immune system, possibly owing to the complexities and functional diversities of cigarette smoke components and individuals' medical condition

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The company, the first to open a laboratory to study tobaccos commercial uses, relocated its research department from New York City to South Richmond in 1929, and ten years later opened a new state-of-the-art research facility where advances took place in tobacco cultivation and processing, as well as research into the health ramifications of tobacco