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In the UK in 2023: 11.9% of people aged 18 years + smoked cigarettes 25 to 34 years had the highest proportion of current smokers in the UK (14.0%) men were more likely to smoke than women, with (13.7% and 10.1%, respectively) Read more ons.gov.uk/peoplepopulati In the UK in 2023: 11.9% of people aged 18 years + smoked cigarettes 25 to 34 years had the highest proportion of current smokers in the UK (14.0%) men were more likely to smoke than women, with (13.7% and 10.1%, respectively) Read more ons.gov.uk/peoplepopulati 9.8% of adults aged 16 years + used e-cigarettes daily or occasionally in Great Britain, 2023 (Opinions & Lifestyle Survey)

Specifically, nicotine and its primary metabolite cotinine are metabolized by the uridine 5-diphospho-glucuronosyltransferase (UGT) superfamily enzymes: specifically UGT2B10 for nicotine and cotinine, and UGT2B7, UGT2B15, and UGT2B17 are responsible for metabolizing androgens