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For example, a 2021 mice study published in the Journal of Molecular Medicine found that full-body exposure to vape vapor may prompt the immune system to release more cytokines - chemical messengers that induce inflammation - which then accumulate in the superficial parts of the eye responsible for light absorption, as well as nourishment and protection of the deeper eye tissues

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So Selye began to suggest that subjecting an animal to prolonged stress led to tissue changes and physiological changes with the release of certain hormones, that would then cause disease and ultimately the death of the animal." And so the idea of stress and it's potential costs to the body was born