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However, the investigators said they tried to limit expectation effects by recruiting only participants with no strong product preference. Dr

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Instead, e-cigarettes are regulated as tobacco products and may be legally marketed only if they receive FDA authorisation, primarily through the PMTA pathway [6]

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Another ligand for RAGE is the nuclear protein high-mobility group box-1 (HMGB1), which is normally buried deep within the nucleus and can be released into the extracellular space by passive diffusion from necrotic cells or by active secretion from activated macrophages/monocytes