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Nicotine interferes with catecholamine and brainstem autonomic nuclei development during the rodent prenatal period (first and second trimester in humans), alters the neocortex, hippocampus, and cerebellum during the early rodent postnatal period (third trimester in humans) and influences the limbic system and later monoamine-containing neuron maturation during adolescence (Dwyer et al., 2009)

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Interestingly, the presence of cough, coryza, runny nose, hoarseness, conjunctivitis, and diarrhea make infection with GAS less likely

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