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Isoform A, the primary form, consists of 222 amino acids and plays a key role in breaking down cytosolic glutathione, essential for maintaining redox balance and supplying amino acids like cysteine and glycine

The 1st glutathione-interaction site, also termed glutathione-scaffold site, is rather well defined and comprises several protein areas that altogether contribute to catalysis by interacting with the glutathione moiety of GSSR 7,8,1315,35 , therefore explaining the specificity for the -glutamyl moiety 9,49,50

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Unraveling the role of HIF-1 in sepsis: from pathophysiology to potential therapeutics-a narrative review

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