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[DOI] [PubMed] [Google Scholar] 47.Chen R, Wang J, Dai X, Wu S, Huang Q, Jiang L, et al

The therapeutic era of peptides began in 1921 with the discovery of insulin, a breakthrough that revolutionized diabetes and helped establish biologic therapies in medicine Since then, peptide hormones like oxytocin and human growth hormone (GH) have entered clinical use, and glucagon-like peptide-1 (GLP-1) receptor agonists such as semaglutide are now widely prescribed for obesity and metabolic diseaseconditions increasingly recognized for their effect on orthopaedic outcomes

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Del Giorno R, Skaper S, Paladini A, Varrassi G, Coaccioli S.Palmitoylethanolamide in Fibromyalgia: Results from Prospective andRetrospective Observational Studies