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While someone under the legal age of sale could also access specialist tobacconists, they are less of a concern because: the number of these retailers is small their products are typically not aimed at young people they are typically in areas with fewer young customers than duty-free shops When the existing tobacco regulations were introduced, the government position was that: fewer people would see bulk products in settings like duty-free shops the bulk-size would be less appealing to children and adults trying to quit Evidence suggests that a reduced price and increased volume of a product is more likely to attract purchases (Watt and others, 2022)

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S1AC) of the differentially expressed genes (DEGs) demonstrate that DA vapor altered transcriptomic expression in NHBECs

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