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Tobacco kills more than 8 million people each year including 1.3 million non-smokers who are exposed to second-hand smoke

PRKN dysfunction accelerates aging phenotypes and shortens lifespan, whereas its overexpression exerts protective effects 33

Smoking also instigates or advances diabetic kidney disease, which is the most common cause of kidney failure

Johns Wort for smoking cessation found that the intervention may result in fewer smokers quitting (10 fewer per 1000, 95% CI 40 fewer to 83 more), compared with placebo, although there was very serious imprecision.22 Other interventions Data on hypnotherapy, continuous auricular stimulation, laser therapy, and electrostimulation were all very uncertain