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Nevertheless, this is the first independent qualitative interview study of IQOS, which was deliberately informed by consultations with experts and smokers/ex-smokers to prioritise key areas of research and policy relevance, and used multiple recruitment methods to access a diverse sample with a range of views and experiences

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Recent experimental studies have demonstrated that prolong exposure to concentrated appropriate PM 2.5 promotes the efflux of Ly6hi + monocytes (CD11b + Gr-1low7/4hi cells) from the bone marrow and, in addition, encourages their subsequent relocation to adipose tissues, the vasculature, and other inflamed tissue, which provides an explanation for the existence of this reaction (75)