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The Lung Health Study showed that using nicotine gum combined with intensive cognitive behavioural therapy (CBT) was effective and safe for helping these subjects to quit smoking.11,12 Later, Tnnesen and Mikkelsen,13 in a randomised, open-label study in which they used 4 forms of nicotine replacement therapy (NRT), found that, at the one-year follow-up, those who had received active treatment quit smoking more often than those who used placebo (5.6%

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While regulations still set strict limits, pack innovation is shifting toward sustainability and personalization

In contrast, high doses (3078 mg/kg) tended to decrease nicotine self-administration (Bruijnzeel and Markou, 2003

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