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They can range in size from a few millimeters to several centimeters and are on the tissue surface or deep into the tissues

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As described in detail above, quantitatively synthesizing heterogeneous studies is scientifically inappropriate and the findings of such meta-analyses are therefore invalid. 177 With his junior colleague Sara Kalkhoran, Glantz went on to publish the study in Lancet Respiratory Medicine in 2016, 178 only to be sharply criticised by tobacco experts writing for independent science communication charity, the Science Media Centre

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