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Pointwise p-values The left-sided p-values (appropriate because the treatment effect is negative) show significance at the 5% level in 8 of 12 post-treatment years: Time | Treatment Effect Left-sided p-value 1989 | -7.4201 0.0500 1990 | -9.5789 0.1000 1991 | -13.2182 0.1500 1992 | -13.9061 0.1000 1993 | -17.6228 0.0500 1997 | -23.8174 0.0500 2000 | -25.5478 0.0500 The four years with weaker significance (19901992 and 1998, with p = 0.100.15) reflect periods when the treatment effect was smaller in magnitude

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Annu Rev Nutr 35:135173 Roca-Ferrer J, Pujols L, Agusti C, Xaubet A, Mullol J, Gimferrer JM, Picado C (2011) Cyclooxigenase-2 levels are increased in the lung tissue and bronchial tumors of patients with chronic obstructive pulmonary disease