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Based on the previous study, it was reported that smokers true level of nicotine dependence could be underestimated by only relying on the number of cigarettes per day ( For the correlation analysis, the volume of several regions including the right inferior frontal gyrus, the right insula, the right middle frontal gyrus, the left precuneus and the right cerebellum anterior lobe were significantly correlated with the pack-years

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[43] The boiling point for nicotine is 247 C

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