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Addiction & Dependence as well as the habit-forming physical practice of vaping (especially socially), most vapes contain nicotine, which is a highly addictive drug

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The present smokers presented with hyperdynamic circulation and enhanced wave reflection when compared with previous smokers, while the previous smokers had increased upright systemic vascular resistance and lower cardiac output when compared with never smokers

This is predictable, because the higher dose of nicotine delivered by e-cigarettes can effectively surmount nicotine tolerance, satisfying the drive for a nicotine "buzz." Switching to e-cigarettes would only be harm-reducing if the products cause less health damage than traditional cigarettes