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While e-cigarettes are considered less harmful than regular cigarettes (the aerosol generally contains fewer toxic chemicals than the 7,000 found in regular cigarette smoke), that doesnt mean they are safe, according to the CDC

It may also lower the quality of sperm and this can make it difficult to fertilize an egg

Though the randomized control trial is seen as the gold standard for untangling correlation from causation, practicality and ethics often mean we have to make do, says Dennis Cook, a professor of statistics at the University of Minnesota

Acknowledging them is the first step toward managing them