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Oxidative damage of proteins was also measured by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) of guinea lung microsomal proteins as described before (4)

They found that men who smoked one cigarette per day had 46% of the excess risk of heart disease and 41% of the excess risk of stroke associated with smoking 20 cigarettes per day (much higher than the expected one 20th, or 5%)

But, that's not all bad news, as the American explains that the image of 'black lungs' made notorious by warnings to stay away from cigarettes is actually a 'little misleading'